The “Gut Brain” and Digestive Health

Proper gastrointestinal motility is essential for optimal rates of nutrient and fluid absorption, elimination of toxins and overall abdominal comfort. GI motility is regulated by over 100 million neurons embedded in the walls of the GI tract.

Collectively known as the enteric nervous system, or the “gut brain,” these neurons communicate by way of numerous neurotransmitters and neurohormones to coordinate smooth muscle contraction.

Serotonin and acetylcholine are the principal neurotransmitters within the GI tract that stimulate motility. Conversely, melatonin helps to modulate these signals to maintain slower neuromuscular rhythms

MotilPro 5-HTP Prokinetic Supplement Australia

MotilPro supports serotonergic and cholinergic neurotransmission in the G.I. tract (1).

5 Hydroxytryptophan (5-HTP) is absorbed by enterochromaffin cells in the epithelium and is decarboxylated to serotonin using pyridoxal 5' phosphate as a cofactor (2).

Serotonin stimulates enteric neurons through activation of 5-HT4 receptors, which contribute to healthy motility (3).

Ginger modulates serotonin signalling by additional 5-HT4 stimulation and by modulating serotonin type 3 (5-HT3) receptors in the enteric nervous system and brain stem, supporting gastric emptying, intestinal transit, healthy visceral sensation and upper G.I. comfort (4).

Acetyl-l-carnitine supports autonomic neuronal health and contributes acetyl groups for the synthesis of acetylcholine (5)*

Motilpro is often recommended as a part of SIBO treatment protocol due to its prokinetic functions.

How Does Motilpro Work?

Motilpro Ingredients:

Serving Size: 3 Capsules | Servings Per Container: 60 | Amount Per Serving / % DV
Vitamin B6 (As Pyridoxal 5' Phosphate) (Activated B6) 6.7mg / 335%
Ginger (Zingiber Officinale) Extract (Root) 1‚000mg / *(Standardized to contain 5% Gingerols)
Acetyl-L-Carnitine (Free-Form) 500mg / *
5-Hydroxytryptophan 50mg / *
*Daily Value not established.
Other Ingredients: Vegetarian capsule (cellulose‚ water)‚ ascorbyl palmitate.

If pregnant, breastfeeding, currently taking any medication or have any significant health history consult your health-care practitioner before using this product.

* These statements have not been evaluated by the Food and Drug Administration or TGA. This product is not intended to diagnose, treat, cure, or prevent any disease. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship.

References

1. Sanger GJ, et al. Eur J Pharmacol. 1986 Aug 15;127(3):179-85.

2. Ahlman H, et al. Acta Physiol Scand. 1981 Jul;112(3):263-9.

3. Wang L, et al. Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G419-28.

4. Huang Q, et al. Yakugaku Zasshi. 1990 Dec;110(12):936-42.

5. White HL, et al. Neurochem Res. 1990 Jun;15(6):597-601.